研究業績
2024年
- Koike, A. Hayashi, K., Fujimori, K. Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis. Eur. J. Pharmacol. 972: 176572 (2024)
- Nakatsuji, M., Fujimori, K. Adipocyte-conditioned medium induces tamoxifen resistance by activating PI3K/Akt/mTOR pathway in estrogen receptor-positive breast cancer cells. Biochim. Biophys. Acta Mol. Cell Res. 1871: 119821 (2024)
- Iguchi, Y., Yamashita, Y., Gohda, K., Oda, K., Fujimori, K., Sera, Y., Imanaka, T., Yamaguchi, M., Une, M., Teno, N. FXR antagonist FLG249 lowers hepatic triacylglycerol and serum cholesterol level in high-fat diet-induced obese mice.Biol. Pharm. Bull. 47: 1429-1436 (2024)
2023年
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Nakatsuji, M., Sato, N., Sakamoto, S., Watanabe, K., Teruuchi, Y., Takeuchi, M., Inui, T., Ishihara, H. Non-electrostatic interactions associated with aggregate formation between polyallylamine and Escherichia coli. Sci. Rep. 13: 14793, 2023
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Yamashita, Y., Gohda, K., Iguchi, Y., Fujimori, K., Oda, K., Masuda, A., Une, M., Teno, N. Discovery of FXR/PPARγ dual partial agonist. Bioorg. Med. Chem. 85: 117238 (2023)
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Pan, L., Trimarco, A., Zhang, A.J., Fujimori, K., Urade, Y., Sun, L.O., Taveggia, C., Zhang, Y. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. eLife 12: e77441 (2023)
2022年
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Fujimori, K., Uno, S., Kuroda, K., Matsumoto, C., Maehara, T. Leukotriene C4 synthase is a novel PPARγ target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes. Biochim. Biophys. Acta Mol. Cell Res. 1869: 119203 (2022)
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2021年
- Maehara, T., Fujimori, K. Inhibition of prostaglandin F2α receptors exaggerates HCl-induced lung inflammation in mice. Int. J. Mol. Sci. 22: 12843 (2021)
- Tse, J. Y., Koike, A., Kadota, K., Uchiyama, H., Fujimori, K., Tozuka, Y. Porous particles and novel carrier particles with enhanced penetration for efficient pulmonary delivery of antitubercular drugs. Eur. J. Pharm. Biopharm. 167: 116–126 (2021).
- Yamamoto, M., Nagasawa, Y., Fujimori, K. Glycyrrhizic acid suppresses early stage of adipogenesis through repression of MEK/ERK-mediated C/EBPβ and C/EBPδ expression in 3T3-L1 cells. Chem. Biol. Interact. 346: 109595 (2021)
- Sugimoto, M., Ko, R., Goshima, H., Koike, A., Shibano, M., and Fujimori, K. Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells. Neurotoxicology 85: 186-200 (2021).
- Koike, A., Tsujinaka, K., and Fujimori, K.
Statins attenuate antiviral IFN-b and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages. FEBS J. 288: 4249–4266 (2021) [Editor’s Choice]
- Gohda, K., Iguchi, Y., Masuda, A., Fujimori, K., Yamashita, Y., Teno, N. Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism. Bioorg. Med. Chem. Lett. 41: 128026 (2021)
- Teno, N., Iguchi, Y., Oda, K., Yamashita, Y., Masuda, A., Fujimori, K., Une, M., Gohda, K. Discovery of orally active and nonsteroidal farnesoid X Receptor (FXR) antagonist with propensity for accumulation and responsiveness in ileum. ACS Med. Chem. Lett. 12: 420–425 (2021)
- Sano, A., Maehara, T, Fujimori, K. Protection of 6-OHDA neurotoxicity by PGF2α through FP-ERK-Nrf2 signaling in SH-SY5Y cells. Toxicology 450: 152686 (2021)
2020年
- Maehara, T., Higashitarumi, F., Kondo, R., Fujimori, K. Prostaglandin F2α receptor antagonist attenuates LPS‐induced systemic inflammatory response in mice. FASEB J. 34: 15197-15207 (2020)
- Kawakami, T., Koike, A., Maehara, T., Hayashi, T., and Fujimori, K. Bicarbonate enhances the inflammatory response by activating JAK/STAT signaling in LPS+IFN-γ-stimulated macrophages. J. Biochem.167: 623-631 (2020)
- Masuda, A., Gohda, K., Iguchi, Y., Fujimori, K., Yamashita, Y., Oda, K., Une, M., and Teno, N. N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR). Bioorg. Med. Chem. 28: 115512 (2020)
- Shinohara, S., Fujimori, K. Promotion of lipogenesis by PPARγ-activated FXR expression in adipocytes. Biochem. Biophys. Res. Commun. 527: 49-55 (2020)
- Maehara, T., Fujimori, K. Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 1865: 158654 (2020)
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2019年
- Fujimori, K., Iguchi, Y., Yamashita, Y., Gohda, K., Teno, N. Synthesis of novel farnesoid X receptor agonists and validation of their efficacy in activating differentiation of mouse bone marrow-derived mesenchymal stem cells into osteoblasts. Molecules 24: 4155 (2019)
- Matsumoto, C., Maehara, T., Tanaka, R., Fujimori, K. Limonoid 7-deacetoxy-7-oxogedunin from andiroba, Carapa guianensis, Meliaceae, decreased body weight gain, improved insulin sensitivity, and activated brown adipose tissue in high-fat-diet-fed mice. J. Agric. Food Chem. 67: 10107-10115 (2019)
- Koike, A., Hanatani, M., Fujimori, K. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp. Cell Res. 380: 171-179 (2019)
- Teno, N., Yamashita, Y., Masuda, A., Iguchi, Y., Oda, K., Fujimori, K., Hiramoto, T., Nishimaki-Mogami, T., Une, M., Gohda, K. Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists. Bioorg. Med. Chem. 27: 2220–2227 (2019)
- Matsumoto, C., Koike, A., Tanaka, R., Fujimori, K. A limonoid, 7-deacetoxy-7-oxogedunin (CG-1) from andiroba (Carapa guianensis, Meliaceae) lowers the accumulation of intracellular lipids in adipocytes via suppression of IRS-1/Akt-mediated glucose uptake and a decrease in GLUT4 expression. Molecules 9: molecules-490535 (2019)
- Fujimori, K., Aritake, K., Oishi, Y., Nagata, N., Maehara, T., Lazarus, M., Urade, Y. L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance. Sci. Rep. 9: 1931 (2019) 【プレスリリース】
2018年
- Nagai, S., Matsumoto, C., Shibano, M., Fujimori., K. Suppression of fatty acid and triglyceride synthesis by the flavonoid orientin through decrease of C/EBPδ expression and inhibition of PI3K/Akt-FOXO1 signaling in adipocytes. Nutrients 10: nutrients-240954 (2018)
- Teno, N., Yamashita, Y., Iguchi, Y., Fujimori, K., Une, M., Nishimaki-Mogami, T., Hiramoto, T., Gohda, K. Non-acidic chemotype possessing N-acylated piperidine moiety as potent farnesoid X receptor (FXR) antagonists. ACS Med. Chem. Lett. 9: 78-83 (2018)
- Watanabe, R., Kurose, T., Morishige, Y., Fujimori, K. Protective effects of fisetin against 6-OHDA-induced apoptosis by activation of PI3K-Akt signaling in human neuroblastoma SH-SY5Y cells. Neurochem. Res. 43: 488-499 (2018)
- Kawakami, T., Koike, A., Amano, F. Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ. Nitric Oxide. 79: 45-50 (2018)
- Kitahiro, Y., Koike, A., Sonoki, A., Ozaki, K., Shibano, M. Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal fibroblasts. J. Nat. Med., 72: 905-914 (2018)
2017年
- Wakai, E., Aritake, K., Urade, Y., Fujimori, K. Prostaglandin D2 enhances lipid accumulation through suppression of lipolysis via DP2 (CRTH2) receptors in adipocytes. Biochem. Biophys. Res. Commun. 490: 393-399 (2017)
- Kawakami, T., Koike, A., Amano, F. Induction of different activated phenotypes of mouse peritoneal macrophages grown in different tissue culture media. Cytotechnology 69: 631-642 (2017)
- Morishige, Y., Koike, A., Tamaura-Ueyama, A., Amano, F. Induction of viable but nonculturable Salmonella in exponentially grown cells by exposure to a low-humidity environment and their resuscitation by catalase. J. Food Prot. 80: 288-294 (2017)
- Tamaki, R., Koike, A., Kanai-Mori, A., Morishige, Y., Koike, A., Yanagihara, K., Amano, F. Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line. Oncol. Rep. 37: 2366-2374 (2017)
2016年
- Baba, S., Ueno, Y., Kikuchi, T., Tanaka, R., Fujimori, K. A limonoid kihadanin B from immature Citrus unshiu peels suppresses adipogenesis through the repression of Akt-FOXO1-PPARγ axis in adipocytes. J. Agric. Food Chem. 64: 9607-9615 (2016)
- Nakao, Y., Yoshihara, H., Fujimori, K. Suppression of very early stage of adipogenesis by baicalein, a plant-derived flavonoid through reduced Akt-C/EBPα-GLUT4 signaling-mediated glucose uptake in 3T3-L1 adipocytes. PLoS ONE 11e0163640 (2016)
- Gambo, Y., Matsumura, M., Fujimori, K. Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms. Mol. Cell. Endocrinol. 431: 1-11 (2016)
- Nagai, S., Wakai, E., Shibano, M., Fujimori, K. Anti-obesity effects of Asian dayflower, Commelina communis, in mice with high-fat diet-induced obesity and in 3T3-L1 cells. J. Funct. Foods 22: 490-503 (2016)
- Bessho, T., Okada, T., Kimura, C., Shinohara, T., Tomiyama, A., Imamura, A., Kuwamura, M., Nishimura, K., Fujimori, K., Shuto, S., Ishibashi, O., Kubata, K., Inui, T. Novel characteristics of Trypanosoma brucei guanosine 5'-monophosphate reductase distinct from host animals. PLoS Negl. Trop. Dis. 10: e0004339 (2016)
- Kawakami, T., Kawamura, K., Fujimori, K., Koike, A., Amano, F. Influence of the culture medium on the production of nitric oxide and expression of inducible nitric oxide synthase by activated macrophages in vitro. Biochem. Biophys. Rep. 5: 328-334 (2016)
- Koike, A., Shibano, M., Mori, H., Kohama, K., Fujimori, K., Amano, F. Simultaneous addition of shikonin and its derivatives with lipopolysaccharide induces rapid macrophage death. Biol. Pharm. Bull. 39: 969-976 (2016)
2015年
- Watanabe, M., Hisatake, M., Fujimori, K. Fisetin suppresses lipid accumulation in mouse adipocytic 3T3-L1 cells by repressing GLUT4-mediated glucose uptake through inhibition of mTOR-C/EBPα signaling. J. Agric. Food Chem. 63: 4979-4987 (2015)
- Koike, A., Minamiguchi, I., Fujimori, K., Amano, F. Nitric oxide is an important regulator of heme oxigenase-1 expression in the lipopolysaccharide and interferon-g-treated murine macrophage-like cell line J774.1/JA-4. Biol. Pharm. Bull. 38: 7-16 (2015)
2014年
- Yuyama, M., Fujimori, K. Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes. Biochem. J. 459: 489-503 (2014)
- Fujimori, K., Yano, M., Miyake, H., Kimura, H. Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis. Mol. Cell. Endocrinol. 384: 12-22 (2014)
- Kimura, H., Fujimori, K. Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells. Gene 534: 169-176 (2014)
- Fujimori, K., Urade, Y. Transcriptional regulation in adipogenesis through PPARγ-dependent and -independent mechanisms by prostaglandins., 1164: 177-196, Transcription Factor Regulatory Networks. Methods in Molecular Biology (Eds.: Miyamoto-Sato, E., Ohashi, H., Sasaki, H., Nishikawa, J.-i., Yanagawa, H.) Springer, Berlin, Heidelberg, Germany (2014)
- Gohda, K., Fujimori, K., Teno, N., Wanaka, K., Tsuda, Y. Synthetic substrates specific to activated plasmin can monitor the enzymatic functional status in situ in breast cancer cells. Chem. Biol. Drug Des. 83: 52-57 (2014)
- Morishige, Y., Tanda, M., Fujimori, K., Mino, Y., Amano, F. Induction of viable but non-culturable (VBNC) state in Salmonella cultured in M9 minimal medium containing high glucose. Biol. Pharm. Bull. 37: 1617-1625 (2014)
- 当麻成人、林 哲也、西野隆雄、銭田晃一、東 剛志、藤森 功、戸塚裕一、松村人志、阪本恭子、山沖留美、芝野真喜雄、佐藤健太郎、小森勝也、藤田芳一. 在宅医療の充実に向けて―地域医療での薬剤師の新たな役割を考える―. 大阪薬科大学紀要 8: 91-93 (2014)
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- 藤森 功. 脂質メディエーターによる肥満初期の進展制御機構の解明. 薬学研究の進歩 30: 51-56 (2014)
2013年
- Fujimori, K., Shibano, M. Avicularin, a plant flavonoid, suppresses lipid accumulation through repression of C/EBPα-activated GLUT4-mediated glucose uptake in 3T3-L1 cells. J. Agric. Food Chem. 61: 5139-5147 (2013)
- Yasuda, K., Cline, C.B., Vogel, P., Onciu, M., Fatima, S., Sorrentino, B.P., Thirumaran. R.K., Ekins, S., Urade, Y., Fujimori, K., Schuetz, E.G. Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier. Drug Metabol. Dispos. 41: 923-931 (2013)
2012年
- Fujimori, K., Yano, M., Ueno, T. Synergistic suppression of early phase of adipogenesis by microsomal PGE synthase-1(PTGES1)-produced PGE2 and aldo-keto reductase 1B3-produced PGF2α. PLoS ONE 7: e44698 (2012)
- Fujimori, K., Maruyama, T., Kamauchi, S., Urade, Y. Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ12-PGJ2 acting through PPARγ-dependent and independent pathways. Gene 505: 46-52 (2012)
- Kobayashi, T., Fujimori, K. Very long chain-fatty acids enhance adipogenesis through co-regulation of Elovl3 and PPARγ in 3T3-L1 cells. Am. J. Physiol. Endocrinol. Metab. 302:12 E1461-E1471 (2012)
- Endo-Umeda, K., Uno, S., Fujimori, K., Naito, Y., Saito, K., Yamagishi, K., Jeong, Y., Miyachi, H., Tokiwa, H., Yamada, S., Makishima, M. Differential expression and function of alternative splicing variants of human liver X receptor α. Mol. Pharm. 81: 800-810 (2012)
- Fukuhara, A., Yamada, M., Fujimori, K., Miyamoto, Y., Kusumoto, T., Nakajima, H., Inui, T. Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death. Biochem. J. 443: 75-84 (2012)
- Yazaki, M., Kashiwagi, K., Aritake, K., Urade, Y., Fujimori, K. Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level. Mol. Biol. Cell 23: 12-21 (2012)
- Fujimori, K., Fukuhara, A., Inui, T., Allhorn, M. Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. J. Neurochem. 120: 279-291 (2012)
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2011年
- Ono, M., Fujimori, K. Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells. J. Agric. Food Chem. 59: 13346-13352 (2011)
- Suematsu, N., Hosoda, M., Fujimori, K. Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Neurosci. Lett. 504: 223-227 (2011)
- Higashi, K., Kubo, H., Watanabe, H., Fujimori, K., Mikami, T., Kaneko, H. Adipokine ganglioside GM2 activator protein stimulates insulin secretion. FEBS Lett. 585: 2587-2591 (2011)
- Ueno, T. , Fujimori, K. Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor-mediated activation of MEK/ERK-CREB cascade. FEBS J. 278: 2901-2912 (2011)
- Fujimori, K., Amano, F. Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression. Prostaglandins Other Lipid Mediat. 94: 96-103 (2011)
- Fujimori, K., Amano, F. Forkhead transcription factor Foxa1 is a novel target gene of C/EBPβ and suppresses the early phase of adipogenesis. Gene 473: 150-156 (2011)
- Minami, N., Yasuda, T., Ishii, Y., Fujimori, K., Amano, F. Regulatory role of cardiolipin in the activity of an ATP-dependent protease, Lon, from Escherichia coli. J. Biochem. 149: 519-527 (2011)
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2010年
- Fujimori, K., Ueno, T., Amano, F. Prostaglandin F2α suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells. Prostaglandins Other Lipid Mediat. 93: 52-59 (2010)
- Devidze, N., Fujimori, K., Urade, Y., Pfaff, D.W., Mong, J.A. Estradiol regulation of lipocalin-type prostaglandin D synthase promoter activity: Evidence for direct and indirect mechanisms. Neurosci. Lett. 474: 17-21 (2010)
- Fujimori, K., Ueno, T., Nagata, N., Kashiwagi, K., Aritake, K., Amano, F., Urade, Y. Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2α synthase. J. Biol. Chem. 285: 8880-8886 (2010)
- Fujitani, Y., Aritake, K., Kanaoka, Y., Goto, T., Takahashi, N., Fujimori, K., Kawada, T. Pronounced adipogenesis and increased insulin sensitivity by overproduction of prostaglandin D2 in vivo. FEBS J. 277: 1410–1419 (2010)
- Fujimori, K., Amano, F. Involvement of forkhead transcription factor Foxa1 in adipocyte differentiation of mouse mesenchymal stem cells. Bull. Osaka. Univ. Pharm. Sci. 4: 61-73 (2010)
2009年
- Nagata, N., Fujimori, K., Okazaki, I., Oda, H. Eguchi, N., Uehara, Y., Urade, Y. De novo synthesis, uptake, and proteolytic processing of lipocalin-type prostaglandin D synthase, β-trace, in the kidneys. FEBS J. 276: 7146-7158 (2009)
- Suzuki, H., Forrest, A.R.R., van Nimwegen, E., Daub, C.O., Balwierz, P.J., Irvine, K.M., Lassmann, T., Ravasi, T., Hasegawa, Y., de Hoon, M.J.L., Katayama, S., Schroder, K., Carninci, P., Tomaru, Y., Kanamori-Katayama, M., Kubosaki, A., Akalin, A., Ando, Y., Arner, E., Asada, M., Asahara, H., Bailey, T. , Bajic, VB., Bauer, D., Beckhouse, A.G., Bertin, N., Björkegren, J., Brombacher, F., Bulger, E., Chalk, A.M., Chiba, J., Cloonan, N., Dawe, A., Dostie, J., Engström, P.G., Essack, M., Faulkner, GJ., Fink, J.L., Fredman, D., Fujimori, K., Furuno, M., Gojobori, T., Gough, J., Grimmond, S.M., Gustafsson, M., Hashimoto, M., Hashimoto, T., Hatakeyama, M., Heinzel, S., Hide, W., Hofmann, O., Hörnquist, M., Huminiecki, L., Ikeo, K., Imamoto, N., Inoue, S., Inoue, Y., Ishihara, R., Iwayanagi, T., Jacobsen, A., Kaur, M., Kawaji, H., Kerr, M.C., Kimura, R., Kimura, S., Kimura, Y., Kitano, H., Koga, H., Kojima, T., Kondo, S., Konno, S., Krogh, A., Kruger, A., Kumar, A., Lenhard, B., Lennartsson, A., Lindow, M., Lizio, M., MacPherson, C., Maeda, N., Maher, CA., Maqungo, M., Mar, J., Matigian, NA., Matsuda, H., Mattick, JS., Meier, S., Miyamoto S., Miyamoto-Sato, E., Nakabayashi, K., Nakachi, Y., Nakano, M., Nygaard, S., Okayama, T., Okazaki, Y., Okuda-Yabukami, H., Orlando, V., Otomo, J., Pachkov, M., Petrovsky, N., Plessy, C., Quackenbush, J., Radovanovic, A., Rehli, M., Saito, R., Sandelin, A., Schmeier, S., Schönbach, C., Schwartz, A.S., Semple, CA., Sera, M., Severin, J., Shirahige, K., Simons, C., St. Laurent, G., Suzuki, M., Suzuki, T., Sweet, M.J., Taft, R.J., Takeda, S., Takenaka, Y., Tan, K., Taylor, M.S., Teasdale, R.D., Tegnér, J., Teichmann, S., Valen, E., Wahlestedt, C., Waki, K., Waterhouse, A., Wells, C.A., Winther, O., Wu, L., Yamaguchi, K., Yanagawa, H., Yasuda, J., Zavolan, M., Hume, D.A., Arakawa, T., Fukuda, S., Imamura, K., Kai, C., Kaiho, A., Kawashima, T., Kawazu, C., Kitazume, Y., Kojima, M., Miura, H., Murakami, K., Murata, M., Ninomiya, N., Nishiyori, H., Noma, S., Ogawa, C., Sano, T., Simon, C., Tagami, M., Takahashi, Y., Kawai, J., Hayashizaki, Y. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genet. 41: 553-562 (2009)
- Tamura, A., Nishino E., Fujimori, K., Igimi, S., Amano F. Lactoferrin inhibits the acquisition of dry-resistance by Salmonella spp. Biosci. Microflora 23: 81-88 (2009)
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2008年
2007年
- Shimamoto, S., Yoshida, T., Inui, T., Gohda, K., Kobayashi, Y., Fujimori, K., Tsurumura, T., Aritake, K., Urade, Y., Ohkubo, T. NMR solution structure of lipocalin-type prostaglandin D synthase: Evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity. J. Biol. Chem. 282: 31373-31379 (2007)
- Fujimori, K., Watanabe, M., Urade, Y., Ishikawa, K. Increased production of lipocalin-type prostaglandin D synthase in leptomeningeal cells through the contact with astrocytes. Neurosci. Lett. 423: 133-137 (2007)
- Fujimori, K., Aritake K, Urade, Y. A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element binding protein-1c. J. Biol. Chem. 282: 18458-18466 (2007)
- Fujimori, K., Urade, Y. Cooperative activation of lipocalin-type prostaglandin D synthase gene expression by activator protein-2β in proximal promoter and upstream stimulatory factor 1 within intron 4 in human brain-derived TE671 cells. Gene 397: 143-152 (2007)
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- 藤森 功. 肥満防止薬に道!脂肪を蓄積させる酵素を確認. 化学 62: 73 (2007)
2006年
- Fujimori, K., Inui, T., Uodome, N., Kadoyama, K., Aritake, K., Urade, Y. Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity. Gene 375: 14-25 (2006)
2005年
2004年
- Muraki, T., Fujimori, K., Ishizaka, M., Ohe, Y., Urade, Y., Okajima, F., Ishikawa, K. Effects of interleukin-1beta and prostaglandin E2 on prostaglandin D synthase production in cultivated rat leptomeningeal cells. J. Cereb. Blood Flow Metab. 24: 409-418 (2004)
2003年
- Higashi, K., Inagaki, Y., Fujimori, K., Nakao, A., Kaneko, H., Nakatsuka, I. Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J. Biol. Chem. 278: 43470-43479 (2003)
- Fujimori, K., Ohta, D. Heavy metal induction of Arabidopsis serine decarboxylase gene expression. Biosci. Biotech. Biochem. 67: 896-898 (2003)
- Fujimori, K., Fujitani, Y., Kadoyama, K., Kumanogoh, H., Ishikawa, K., Urade, Y. Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1β via two NF-κB elements in rat leptomeningeal cells. J. Biol. Chem. 278: 6018-6026 (2003)
2002年
2001年
- Ueno, N., Murakami, M., Tanioka, T., Fujimori, K., Tanabe, T., Urade, Y., Kudo, I. Coupling between cyclooxygenases, terminal prostanoid synthases and phospholipase A2s. J. Biol. Chem. 276: 34918-34927 (2001)
- Gohda, K., Ohta, D., Kozaki, A., Fujimori, K., Mori, I., Kikuchi, T. Identification of novel potent inhibitors for ATP-phosphoribosyl transferase using three-dimensional structural database search technique. Quant. Struct.-Act. Relat. 20: 143-147 (2001)
2000年
- Fujimori, K., Kanaoka, Y., Sakaguchi, Y., Urade, Y. Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of Oct-1 element in the 5'-flanking region and AP-2 element in the untranslated exon 1. J. Biol. Chem. 275: 40511-40516 (2000)
- Kubata, B.K., Duszenko, M., Kabututu, Z., Rawer, M., Szallies, A., Fujimori, K., Inui, T., Nozaki, T., Yamashita, K., Horii, T., Urade, Y., Hayaishi, O. Identification of a novel prostaglandin F2α synthase in Trypanosoma brucei. J. Exp. Med. 192: 1327-1338 (2000)
- Beuckmann, C.T., Fujimori, K., Urade, Y., and Hayaishi, O. Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain. Neurochem. Res. 25: 733-738 (2000)
- Kanaoka, Y., Fujimori, K., Kikuno, R., Sakaguchi, Y., Urade, Y., Hayaishi, O. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin d synthase. Eur. J. Biochem. 267: 3315-3322 (2000)
- Ohta, D., Fujimori, K., Mizutani, M., Nakayama, Y., Kunpaisal-Hashimoto, R., Münzer, S., Kozaki, A. Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway. Plant Physiol. 122: 907-914 (2000)
1999年
- Inui, T., Ishibashi, O., Origane, Y., Fujimori, K., Kokubo, T., Nakajima, M. Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action. Biochem. Biophys. Res. Commun. 429: 173-178 (1999)
1998年
- Fujimori, K., Ohta, D. An Arabidopsis cDNA encoding a bifunctional glutamine amidotransferase/cyclase suppresses the histidine auxotrophy of a Saccharomyces cerevisiae his7 mutant. FEBS Lett. 428: 229-234 (1998)
- Fujimori, K., Ohta, D. Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphatase and phosphoribosyl-AMP cyclohydrolase. Plant Physiol. 118: 275-283 (1998)
- Fujimori, K.,Tada, S., Kanai, S., Ohta, D. Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana. Mol. Gen. Genet. 259: 216-223 (1998)
1997年
- Fujimori, K.,Anamnart, S., Nakagawa, Y., Sugioka, S., Ohta, D., Oshima, Y., Yamada, Y., Harashima, S. Isolation and characterization of mutations affecting expression of the Δ9-fatty acid desaturase gene, OLE1, in Saccharomyces cerevisiae. FEBS Lett. 413: 226-230 (1997)
- Anamnart, S., Tomita, T., Fukui, F., Fujimori, K., Harashima, S., Yamada, Y., Oshima, Y. The P-OLE1 gene of Pichia angusta encodes a Δ9-fatty acid desaturase and complements the ole1 mutation of Saccharomyces cerevisiae. Gene 184: 299-306 (1997)
1991年
報告書、プロシーディングなど